Preparation and characterization of a novel injectable strontium-containing calcium phosphate cement with collagen
Preparation and characterization of a novel injectable strontium-containing calcium phosphate cement with collagen作者机构：Guang Zhou Red Cross Hospital The Fourth Affiliated Hospital of the Medical College Jinan University Guangzhou 510220 China
出 版 物：《Chinese Journal of Traumatology》 (中华创伤杂志（英文版）)
年 卷 期：2015年第18卷第1期
页 面：33-38页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 08[工学] 071009[理学-细胞生物学] 09[农学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0901[农学-作物学] 090102[农学-作物遗传育种]
主 题：Calcium phosphate cement Injectability Compressive strength
摘 要：Purpose： To develop a novel injectable strontium-containing calcium phosphate cement with collagen. Methods： A novel calcium phosphate bone cement （CPC） was prepared with the addition of strontium element, collagenl, and modified starch; the injectability, solidification time, microstructure, phase composition, compressive strength, anti-collapsibility and histological properties of material were evaluated. Results： The results showed that the material could be injected with an excellent performance; the modified starch significantly improved the anti-washout property of cement; with the liquid to solid ratio of 0.3, the largest compressive strength of cement was obtained （48.0 MPa _＋ 2.3 MPa）; histological examination of repair tissue showed that the bone was repaired after 16 weeks; the degradation of cement was consistent with the new bone growth. Conclusion： A novel injectable collagen-strontium-containing CPC with excellent compressive strength and suitable setting time was prepared, with addition of modified starch. The CPC showed a good anti-washout property and the degradation time of the cement met with the new bone growing. This material is supposed to be used in orthopedic and maxillofacial surgery for bone defects.
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