THE AMPHIPHILIC MULTIARM COPOLYMERS BASED ON HYPERBRANCHED POLYESTER AND LYSINE:SYNTHESIS AND SELF-ASSEMBLY

作     者：黄卫 

作者机构：School of Chemistry and Chemical EngineeringState Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong University 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学（英文版）)

年 卷 期：2011年第29卷第2期

页      面：241-250页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：supported by the National Basic Research Program(Nos.2007CB808000,2009CB930400) the National Natural Science Foundation of China(Nos.50873058,20874060,50633010) Shanghai Leading Academic Discipline Project(No.B202) the Zhejiang Provincial Natural Science Foundation of China(No.Y405411) 

主　　题：N-ε-carbobenzoxy-L-Lysine N-carboxyanhydride Amphiphilic multiarm copolymer Hyperbranched polyester Modification Self-assembly 

摘      要：The amphiphilic multiarm copolymers were synthesized through the modification of commercially available hyperbranched polyesters（Boltorn H40） with N-ε-carbobenzoxy-L-Lysine N-carboxyanhydride（ZLys-NCA）.After being condensed with N-Boc-phenylalanine（Boc-^NPhe） and deprotected the Boc-groups in trifluoroacetic acid（TFA）,the original terminal hydroxyl groups were transformed into the amino groups and then initiated the ring-opening polymerization of *** hydrophilic poly（L-lysine） was grafted to the surface of Boltorn H40 successfully after the protecting benzyl groups were removed by the HBr solution in glacial acetic acid（33 wt%）.The resulting multiarm copolymers were characterized by the ^1H-NMR,GPC and *** arm length calculated by NMR and GPC analysis was about 3 and 13 lysine-units for H40-Phe-PLysl and H40-Phe-PLys2 *** to the amphiphilic molecular structure,they displayed ability to self-assemble into spherical micelles in aqueous solution with the average diameter in the range from 70 nm to 250 *** CMC of H40-Phe-PLysl and H40-Phe-PLys2 was 0.013 mg/mL and 0.028 mg/mL,respectively, indicating that H40-Phe-PLysl with shorter arm length is easier to self-assemble than H40-Phe-PLys2 with longer arm length.