Synthesis of tetracycline analogs and their bone affinities

作     者：Wen Cai Huang Hu Zheng Ling Ling Weng 

作者机构：School of Chemical Engineering Sichuan University Chengdu 610065 China West China School of Pharmacy Sichuan University Chengdu 610041 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2008年第19卷第1期

页      面：19-22页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：This work was supported by the National Natural Science Foundation of China (No. 30070883) 

主　　题：Tetracycline Analogs Bone affinities Hydroxyapatite 

摘      要：Tetracycline analogs were designed and synthesized and their bone affinities were tested on hydroxyapatite. The results showed that the carbonyl-amide-enol structure in A ring and phenol-ketone structure in BCD ring may be responsible for tetracycline＇s high bone affinity and either A ring or BCD ring has a planar conformation is essential. 2007 Ling Ling Weng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.