Tuina for treatment of atopic eczema in children under 14 years: A systematic review of randomized controlled trials

作     者：Chunli Lu Xinyan Jin Darong Wu Sijia Zhu Lily Lai Jianping Liu 

作者机构：Centre for Evidence-Based Chinese MedicineBeijing University of Chinese MedicineBeijing 100029China The Third Affiliated Hospital of Beijing University of Chinese MedicineBeijing 100029China The 2nd Affiliated Hospital of Guangzhou Universality of Chinese MedicineGuangzhou 510000China Primary Care and Population SciencesAldermoor Health CentreSouthamptonSO16 5STUK 

出 版 物：《Journal of Traditional Chinese Medical Sciences》 (中医科学杂志（英文）)

年 卷 期：2019年第6卷第1期

页      面：13-25页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Beijing University of Chinese Medicine  BUCM  (1000061020008) 

主　　题：Tuina Atopic eczema Non-pharmaceutical therapy Pediatrics Systematic review 

摘      要：Objective:Due to a lack of available effective treatments for atopic eczema (AE),non-pharmaceutical therapy such as Tuina has been frequently sought after as an alternative *** evaluated the benefits and harms of Tuina for children with AE under 14 years of ***:We searched for randomized controlled trials (RCTs) on Tuina in seven Chinese and English databases from their inception to June *** included children under 14 years of age with AE received Tuina alone or combined with conventional *** authors independently extracted data and used the Cochrane Risk of bias tool to assess the methodological *** were presented as relative risk with 95% confidence interval using RevMan *** not suitable for statistical pooling were synthesized ***:Nine RCTs involving 1246 children with AE were *** trials were at unclear or high risk of *** manipulation in each trial was *** to usual care,three trials showed greater effects of Tuina alone or combined with usual care for global symptoms and signs improvement,such as itching,and skin *** trials showed that Tuina had 50% improvement in symptoms and *** to clinical heterogeneity,meta-analysis was not *** follow-up of between 4 weeks and 6 months,five trials of Tuina alone or Tuina combined with usual care showed lower rates of relapse compared to usual care *** trials reported no occurrence of severe adverse ***:Limited evidence demonstrates that Tuina may improve symptoms and signs of AE and reduce relapse rate in children 14 yrs with *** is generally acceptable in these *** well-designed RCTs are warranted to confirm these benefits and to explore safety further.