Atomic force microscopy reveals new mechanisms of increased aortic stiffness in hypertension

作     者：Gerald A.Meininger Nancy L.Sehgel Zhu Yi Sun Zhe Hong Zhongkui Michael A.Hill Gao Shumin Jerome P.Trzeciakowski William C.Hunter Dorothy E.Vatner Stephen F.Vatner 

作者机构：Dalton Cardiovascular Research Center and Department of Medical Pharmacology and PhysiologyUniversity of MissouriColumbiaMOUSA Department of Cell Biology and Molecular MedicineUMDNJ-New Jersey Medical SchoolNewarkNJUSA Department of Biomedical EngineeringNew Jersey Institute of TechnologyNewarkNJUSA Department of Systems Biology and Translational MedicineTexas A&M UniversityCollege StationTXUSA 

出 版 物：《泸州医学院学报》 (Journal of Luzhou Medical College)

年 卷 期：2013年第36卷第3期

页      面：310-311页

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 083202[工学-粮食、油脂及植物蛋白工程] 0803[工学-光学工程] 

基　　金：supported in part by NIH grant(NIH P01HL095486) NIH grants(NIH P01HL069020 NIH R01HL093415 NIH R01HL095888) NIH grants(NIH5R01HL102472 NIH P01AG027211 NIH P01HL069020 NIH T32HL069752 NIH R01HL093481 NIHR01HL106511) 

主　　题：发病机制 高血压 原子力显微镜 主动脉 僵硬 健康问题 组成部分 药物治疗 

摘      要：Hypertension is an important global health problem that continues increase in *** vascularstiffness has been identified as an important component of the pathogenesis of hypertension(HT).Based on theresults of recent Framingham studies,it appears that aortic increased stiffness may precede hypertension suggest-ing that controlling arterial stiffness may