Effects of early enteral nutrition on immune function of severe acute pancreatitis patients

作     者：Jia-Kui Sun Xin-Wei Mu Wei-Qin Li Zhi-Hui Tong Jing Li Shu-Yun Zheng 

作者机构：Department of Intensive Care UnitNanjing First HospitalNanjing Medical University Department of General SurgeryJinling HospitalNanjing University School of Medicine 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第6期

页      面：917-922页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Grants from the Key Project of the Eleventh Five-Year Plan of People's Liberation Army No.06G041 

主　　题：Early enteral nutrition Immune Severe acute pancreatitis 

摘      要：AIM:To investigate the effects of early enteral nutrition (EEN) on the immune function and clinical outcome of patients with severe acute pancreatitis (SAP).METHODS:Patients were randomly allocated to receive EEN or delayed enteral nutrition (DEN).Enteral nutrition was started within 48 h after admission in EEN group,whereas from the 8 th day in DEN *** the immunologic parameters and C-reactive protein (CRP) levels were collected on days 1,3,7 and 14 after *** clinical outcome variables were also ***:Sixty SAP patients were enrolled to this *** CD4+ T-lymphocyte percentage,CD4+/CD8+ ratio,and the CRP levels in EEN group became significantly lower than in DEN group from the 7 th day after *** contrast,the immunoglobulin G(IgG) levels and human leukocyte antigen-DR expression in EEN group became significantly higher than in DEN group from the 7 th day after *** difference of CD8+ T-lymphocyte percentage,IgM and IgA levels was found between the two *** incidences of multiple organ dysfunction syndrome,systemic inflammatory response syndrome,and pancreatic infection as well as the duration of intensive care unit stay were significantly lower in EEN group than in DEN ***,there was no difference of hospital mortality between the two ***:EEN moderates the excessive immune response during the early stage of SAP without leading to subsequent *** can improve the clinical outcome,but not decrease the hospital mortality of SAP patients.