Structural and functional insights into MCR-2 mediated colistin resistance

作     者：Xudong Wang Qiong Lu Jianxun Qi Yan Chai Youchun Wang George Fu Gao 

作者机构：CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences College of Life Sciences University of Chinese Academy of Sciences Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products Division of HIV/AIDS and Sexually Transmitted Virus Vaccines National Institutes for Food and Drug Control National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention (China CDC) Research Network of Immunity and Health (RNIH) Beijing Institutes of Life Science Chinese Academy of Sciences 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2018年第61卷第11期

页      面：1432-1436页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 

基　　金：supported by the Chinese Academy of Sciences (CAS) Strategic Priority Research Program (XDB08020100) the External Cooperation Program of Chinese Academy of Sciences (153211KYSB20160001) the National Key Plan for Scientific Research and Development of China (2016YFD0500305) 

主　　题：colistin resistance genes bacteria 

摘      要：Dear Editor,The spread of antibiotic resistance genes among bacteria is a serious and growing threat to global health (Peleg and Hoopet,2010).One emerging case is transferable genes found in bacteria-encoding enzymes resistant to colistin.Colistin is a cationic polypeptide antibiotic with broadspectrum activity against Gram-negative bacteria through interactions with the lipid A moiety of bacterial lipopoly-saccharide(LPS),subsequently destroying the cell envelope.During late 2015,a plasmid-mediated gene,mcr-1,was first reported from Escherichia coli(E.coli)in China to confer resistance to colistin(Liu et a1.,2016),and detected world-wide soon afterwards(Gao et a1.,2016;Hu et a1.,2016).