Antibacterial Activity of Polymeric Quaternary Ammonium Compounds Tuned by Incorporating Hydrophilic co-Monomer

作     者：ZUO Huajiang WEN Wanhua WU Dingcai FU Ruowen TANG Chunyi 

作者机构：PCFM Laboratory School of Chemistry and Chemical Engineering Sun Yat-sen University Guangzhou 510275 P R. China College of Biological and Chemical Engineering Guangxi University of Science and Technology Liuzhou 545006 P. R. China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2015年第31卷第1期

页      面：160-166页

核心收录：

学科分类：082903[工学-林产化学加工工程] 08[工学] 0829[工学-林业工程] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 082201[工学-制浆造纸工程] 0822[工学-轻工技术与工程] 

基　　金：Supported by the National Natural Science Foundation of China(No.50673101)  the Scientific Foundation of Guangdong Province of China(Nos.0711020600015  2004A30404001)  the Natural Science Foundation of Guangxi Zhuang Autonomous Region of China(Nos.2013GXNSFBA019040  2013GXNSFBA019036)  the Projcet of Department of Education of Guangxi Zhuang Autonomous Region  China(No.2013YB171) and the Foundation of Guangxi University of Science and Technology  China 

主　　题：Polymeric quaternary ammonium compound Antibacterial mechanism Copolymerization Hydrophobic/hydrophilic balance 

摘      要：Copolymers of quaternary ammonium monomer（QAM） and hydrophilic co-monomer were successfully synthesized by free radical polymerization. It was discovered that the hydrophilic co-monomers with poor antibac- terial activity significantly enhanced the activity of QAM substituted with a long alkyl chain[i.e., N,N-dimethyl-N-dodecyl methacrylate ammonium bromide（DMAEMA-DB）]. When a suitable molar ratio of DMAEMA-DB to co-monomer was selected, the activity of the copolymers was up to 123 times that of the homopolymer of DMAEMA-DB against S. aureus, and 282 times that of it against E. colt. But unlike DMAEMA-DB, the co-monomers might weaken the activity of QAM substituted with a short alkyl chain[i.e., N,N-dimethyl-N-butyl methacrylate ammonium bromide（DMAEMA-BB）]. Moreover, it was found that copolymers of DMAEMA-DB were much more biocidal than those of DMAEMA-BB. Therefore, it could be speculated that the long alkyl chain plays an important role in the antibacterial activity, and that the hydrophilie co-monomers are beneficial to polymeric guaternary ammonium compounds（PQACs） to exert the positive effect of the long alkyl chain to the greatest degree.