Role of ghrelin in cognitive impairment of hypertensive elders with chronic psychological distress

作     者：Zhang Yushun Fan Fenling Tian Hongyan Feng Jun Ma Xiancang Liu Yamin Hu Zhi Zhang Junbo Ma Yexin 

作者机构：Department of Cardiology Tongji Hospital Tonggji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Cardiovascular Medicine First Affiliated Hospital Medical College Xi 'an Jiaotong University Xi 'an 710061 China Department of Psychology and Psychiatry First Affiliated Hospital Medical College Xi 'an Jiaotong University Xi 'an 710061 China 

出 版 物：《Journal of Medical Colleges of PLA(China)》 (中国人民解放军军医大学学报（英文版）)

年 卷 期：2010年第25卷第3期

页      面：163-172页

学科分类：0710[理学-生物学] 07[理学] 0905[农学-畜牧学] 09[农学] 071006[理学-神经生物学] 090501[农学-动物遗传育种与繁殖] 

主　　题：Ghrelin Hypertension Cognitive impairment Psychological stress Elder 

摘      要：Objective:To investigate ghrelin level change in combination with psychological stress in the hypertensive old people with cognitive impairment and to explore its effect as well as possible ***:The study population of 300 elders was divided into 2 groups,148 with hypertension and 152 non-hypertension,who were screened for psychological distress and cognition function,and had blood drawn to measure plasma levels of ghrelin and total cortisol on the same ***:The rates of anxiety and cognitive impairment were higher in the hypertension elders,which were negatively correlated with plasma ghrelin level,resulted from chronic cortisol response to ***:Chronic plasma cortisol increase to long-term anxiety leads a reduce in ghrelin level which then adversely affects blood pressure and cognitive function in old *** measuring ghrelin of elders may be a diagnostic tool to predict cognitive development and ghrelin may be a selective antihypertensive medicine for cognitive impairment elders with or without chronic psychological stress.