无胸腺瘤的重症肌无力患者其变应性结膜炎的高发病率

作     者：MuraiH. OsoegawaM. OchiH. KiraJ. 杨建刚 

出 版 物：《世界核心医学期刊文摘（眼科学分册）》 (Digest of the World Core Medical Journals:Ophthalmology)

年 卷 期：2005年第1卷第3期

页      面：9-9页

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 100204[医学-神经病学] 10[医学] 

主　　题：重症肌无力 胸腺瘤 变应性结膜炎 肌无力危象 变应性疾病 眼部异常 发病频率 血清反应 对照组人群 医院神经科 

摘      要：To investigate the frequency of allergic disorders in myasthenia gravis (MG) p atients and characterize the features of MG associated with allergic disorders. Frequencies of past and present common allergic disorders in 160 MG patients who visited the Department of Neurology, Kyushu University Hospital from April 2000 to July 2003 and in 81 neurological normal controls were studied. Among various allergic disorders, the frequency of allergic conjunctivitis (AC) was significa ntly higher in MG patients (39/160, 24.4%, Pcorr=0.011 2), especially with MG w ithout thymoma (36/123, 29.3%, Pcorr=0.001 6), in comparison to the controls (6 /81, 7.4%). MG patients with AC showed a significantly higher rate of seronegat ive MG (43.6%vs. 17.4%, P=0.008) and a higher tendency of ocular MG (43.6%vs. 28.1%, P=0.071). Moreover, MG with AC had significantly lower anti acetylchol ine receptor antibody titers (median 6.8 nmol/L vs. median 23.6 nmol/l, P=0.035 9) as well as a lower rate of coexisting thymoma (7.7%vs. 17.4%, P=0.016). The incidence of myasthenic crisis was also lower in MG with AC than without AC, ye t the difference was not significant (7.7%vs. 15.7%). There was a significant association of AC with MG especially for ocular or seronegative MG in cases with out thymoma.