Estrogen and its signaling pathway in non-small cell lung cancer(NSCLC)

作     者：Ruitong Xu Yongqian Shu 

作者机构：Department of Oncology the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China 

出 版 物：《Journal of Nanjing Medical University》 (南京医科大学学报（英文版）)

年 卷 期：2009年第23卷第4期

页      面：217-223页

学科分类：0710[理学-生物学] 0810[工学-信息与通信工程] 071010[理学-生物化学与分子生物学] 090602[农学-预防兽医学] 0808[工学-电气工程] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 0906[农学-兽医学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

主　　题：lung cancer estrogen estrogen receptor EGFR 

摘      要：Lung cancer is the most common cancer in the world. It is a highly lethal disease in women and men, and new treatments are urgently needed. Several studies have implicated a role of estrogens and estrogen receptors in lung cancer progression. This review will investigate the biological significance of estrogens in lung cancer cells, the expression and molecular mechanisms of estrogen receptors（ER α and ER β, elucidate the prognostic significance of estrogens and their receptors in lung carcinomas and provide new options for patients afflicted with lung malignancies.