Effect of gating currents of ion channels on the collective spiking activity of coupled Hodgkin-Huxley neurons
Effect of gating currents of ion channels on the collective spiking activity of coupled Hodgkin-Huxley neurons作者机构：School of Physics & Electronic Engineering Ludong University Yantai 264025 China
出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)
年 卷 期：2009年第52卷第1期
页 面：20-25页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
基 金：Supported by the Science Foundation of Ludong University (Grant Nos. 23140301 L20072805)
主 题：neuron gating current channel noise kinetics stochastic process
摘 要：Based on the coupled stochastic Hodgkin-Huxley neurons, we numerically studied the effect of gating currents of ion channels, as well as coupling and the number of neurons, on the collective spiking rate and regularity in the coupled system. It was found, for a given coupling strength and with a relatively large number of neurons, when gating currents are applied, the collective spiking regularity decreases; meanwhile, the collective spiking rate increases, indicating that gating currents can aggravate the de-synchronization of the spikings of all neurons. However, gating currents caused hardly any effect in the spiking of any individual neuron of the coupled system. This result, different from the reduction of the spiking rate by gating currents in a single neuron, provides a new insight into the effect of gating cur-rents on the global information processing and signal transduction in real neural systems.
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