Next generation sequencing, inter-tumor heterogeneity and prognosis of hepatitis B related hepatocellular carcinoma

作     者：Jean-Charles Nault 

作者机构：Inserm UMR-1162 Génomique fonctionnelle des Tumeurs solidesIUH Paris F-75010 France Université Paris Descartes Labex Immuno-Oncology Sorbonne Paris CitéFaculté de Médecine Paris France Service d'Hépatologie Hopital Jean Verdier AP-HP Bondy and Université Paris 13 Bobigny France 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2014年第26卷第6期

页      面：730-731页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by HECAM (BPI), EBCI, INCa (Wnt HCC project). J-C.N supported by a fellowship from INCa 

主　　题：sequencing heterogeneity radiofrequency recurrence impaired ablation prognosis carcinogenesis burden Africa 

摘      要：Hepatocellular carcinoma（HCC）is one of the leading causes of cancer related death in Asia and Africa（1）.It reflects the high burden of hepatitis B virus（HBV）infection in these *** treatments of HCC as radiofrequency ablation and resection are impaired by a high rate of tumor ***,most of the time,HCC is frequently diagnosed at advanced stages where only