Effects of dietary nickel on detoxification enzyme activities in the midgut of Spodoptera litura Fabricius larvae

作     者：SUN HongXia ZHOU Qiang TANG WenCheng SHU YingHua ZHANG GuRen 

作者机构：State key laboratory for Biological Control & Institute of Entomology Sun Yat-sen University Guangzhou 510275 China 

出 版 物：《Chinese Science Bulletin》 (中国科学通报)

年 卷 期：2008年第53卷第21期

页      面：3324-3330页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the National Basic Research Development Program of China (Grant No. 2006CB102001) National Natural Science Foundation of China (Grant No. 30771458) Doctoral Fundaytion of Ministry of Education of China (Grant No. 20070558029) Basic Research Group Programs of Guangdong Province (Grant No.E039254) 

主　　题：镍元素 中肠 羧酸酯酶 转移酶 

摘      要：Nickel accumulated in midugt of Spodoptera litura Fabricius could induce the expression of metal-lothionein,one of the most important detoxification proteins in *** the present study,the effects of dietary nickel on the activities of detoxification enzymes,such as carboxylesterase(CarE) and glutathione S-transferase(GST) in the midgut of *** larvae have been studied to get an un-derstanding of the detoxification mechanisms of *** larvae to excessive *** showed that CarE activities in the midgut of the 5th instar larvae decreased at lower levels of nickel(≤5 mg/kg),while increased with increasing nickel doses at higher levels of nickel(≥10 mg/kg) exposure in suc-cessive 3 *** activities of the 6th instar larvae were also characterized as inhibited at low levels of nickel exposure,and improved at higher levels in the 1st *** activities of 6th instar larvae in the 2nd and 3rd generations were all lower than that in ***,GST activities in the midgut of the 5th and 6th instar larvae all increased with increasing nickel doses(1―20 mg/kg) in diets.