Biocatalytic synthesis of (R)-(-)-mandelic acid from racemic mandelonitrile by a newly isolated nitrilase-producer Alcaligenes sp. ECU0401

作     者：Yu Cai He Jian He Xu Yi Xu Li Ming Ouyang Jiang Pan 

作者机构：Laboratory of Biocatalysis and Bioprocessing State Key Laboratory of Bioreactor Engineering East China University of Science and Technology Shanghai 200237 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2007年第18卷第6期

页      面：677-680页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：National Natural Science Foundation of China, NSFC, (20506037, 20672037) National Natural Science Foundation of China, NSFC 

主　　题：Mandelonitrile Nitrilase (R)-()-Mandelic acid Screening Alcaligenes sp. ECU0401 

摘      要：By using acetonitrile as the sole nitrogen source, a microbial strain with high nitrilase activity, named as Alcaligenes sp. ECU0401, was newly isolated from soil, which could enantioselectively transform racemic mandelonitrile into (R)-(?)-mandelic acid, with an enantiomeric excess of 99.9%.