Lipase-catalyzed hydrolysis of methyl-3-phenylglycidate

作     者：Guo Jun ZHENG Jian Jun WANG Tian Rui REN Liu YANG Wan Ru SUN 

作者机构：State Key Laboratory of Microbial ResourcesInstitute of MicrobiologyCASBeijing100080 Laboratory of Chemistry ComputerInstitute of Chemical MetallurgyCASBeijing100080 

出 版 物：《Chinese Chemical Letters》 (中国化学快报(英文版))

年 卷 期：2001年第12卷第4期

页      面：305-306页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：This work was supported by the National Natural Sciences Foundation of China 

主　　题：Lipase methyl 3-phenylglycidate resolution chirality. 

摘      要：The enzymatic resolution of racemic methyl 3-phenylgycidate was investigated. It was found that the hydrolysis rate of (2S, 3R)-enantiomer was faster than that of (2R. 3S)-enantiomer by a new lipase. At optimal condition 96% of (2R. 3S)-methyl phenylglycidate with ee of 100% was recovered from the racemic mixture.