The novel OCT4 spliced variant OCT4B1 can generate three protein isoforms by alternative splicing into OCT4B

作     者：Yuan Gao Xia Wang Jin Han Zhifeng Xiao Bing Chen Guannan Su Jianwu Dai 

作者机构：Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100190 China The Graduate School Chinese Academy of Sciences Beijing 100190 China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2010年第37卷第7期

页      面：461-465页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 08[工学] 0905[农学-畜牧学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：supported by the National Basic Research Program of China (973 Program) (No 2006CB943601) the National Natural Science Foundation of China (NSFC) (No 90919042) 

主　　题：OCT4 alternative splicing alternative translation initiation stress 

摘      要：OCT4 is one of the key transcription factors in maintaining the pluripotency and self-renewal of embryonic stem （ES） *** OCT4 can generate two isoforms OCT4A and OCT4B by alternative ***4B1 is a recently discovered novel OCT4 spliced variant,which has been considered as a putative marker of *** with the OCT4B mRNA,OCT4B1 mRNA is generated by retaining intron 2 as a cryptic exon which contains a TGA stop codon in *** a result,the protein product of OCT4B1 mRNA could be ***,we present here that OCT4B1 can indirectly produce the same protein products as *** have demonstrated that OCT4B1 mRNA can be spliced into OCT4B mRNA,and encode three protein *** splicing of OCT4B1 mRNA into OCT4B mRNA can be remarkably inhibited by the mutation of the classical splicing *** result suggests that OCT4B mRNA may originate from OCT4B1 mRNA by alternative splicing.