英国西北部视神经发育不全和视隔发育不全的地域分布

作     者：Patel L. Mc Nally R.J.Q. Harrison E. 贺莉 

作者机构：University of Manchester Academic Unit of Child Health Booth Hall Children's Hospital Manchester M9 7AA United Kingdom.Dr 

出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)

年 卷 期：2006年第2卷第5期

页      面：30-30页

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：视神经发育不全 地域分布 英国 标准化发病率 发病率研究 时空聚集性 发育异常 试验设计 危险因素 

摘      要：Objective: To study the distribution of septo-optic dysplasia (SOD) and optic nerve hypoplasia (ONH) in the Greater Manchester and Lancashire (GM&L) region of Northwest England, and to analyze occurrence by location and over time. Study design: A population-based incidence study was undertaken for cases of SOD/ONH from GM&L. Standardized incidence ratio (SIR) for each district, relationships between SIRs and possible geographically varying risk factors, and spatial and space-time clustering were analyzed. Results: Eighty-seven cases had a confirmed diagnosis of ONH/SOD giving an incidence of 10.9/100,000 per year in GM&L. SIRs ranged widely but were significantly elevated (lower confidence limit 100) in three districts: 167%, 192%, and 198%, respectively. All three were high population density, inner-city locations. SIRs were significantly correlated with higher rates of unemployment (r=0.49, P= .01), dependent children in nonearning households (r= 0.47, P= .02), underage conceptions (r= 0.46, P= .02), and underage pregnancies (r=0.44, P= .03). There was no evidence of spatial or space-time clustering. Conclusions: The incidence of ONH/SOD in GM&L was higher than that reported elsewhere. Cases were more common in areas that had higher unemployment and teenage pregnancy rates.