Use of thiopurines in inflammatory bowel disease

作     者：Pascal Frei Luc Biedermann Ole Haagen Nielsen Gerhard Rogler 

作者机构：Division of Gastroenterology and HepatologyDepartment of Internal MedicineUniversity Hospital of ZürichCH-8091 ZürichSwitzerland Department of GastroenterologyMedical SectionHerlev HospitalUniversity of CopenhagenDK-2730 HerlevDenmark 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第7期

页      面：1040-1048页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Thiopurines Inflammatory bowel disease Crohn’s disease Ulcerative colitis Immunosuppression Infection 

摘      要：The use of thiopurines as immunosuppression for the treatment of refractory or chronic active inflammatory bowel disease is established for both Crohn s disease and ulcerative ***,many questions remain concerning the optimal treatment regimens of azathioprine,6-mercaptopurine and *** will briefly summarize dose recommendations,indications for thiopurine therapy and side effects which are relevant in clinical *** discuss some currently debated topics,including the combination of azathioprine and allopurinol,switching of thiopurine therapy in case of side effects,the use of azathioprine in pregnancy,the infection risk using thiopurines and the evidence when to stop *** reviews have been published on the thiopurine metabolic pathway which will not be discussed here in detail.