Overview of Multidrug-Resistant Pseudomonas aeruginosa and Novel Therapeutic Approaches

作     者：Marilyn Porras-Gomez Jose Vega-Baudrit Santiago Nunez-Corrales 

作者机构：National Nanotechnology Laboratory LANOTECNational Center for Advanced Technology CeNATSan JoseCosta Rica E-Science Research ProgramCosta Rican Institute of TechnologyCartagoCosta Rica 

出 版 物：《Journal of Biomaterials and Nanobiotechnology》 (生物材料与纳米技术（英文）)

年 卷 期：2012年第3卷第4期

页      面：519-527页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Bacilli Gram-Negative Pseudomonas aeruginosa Multidrug Resistance Pathogen Resistance Mechanisms 

摘      要：Gram-negative bacilli Pseudomonas aeruginosa is an important pathogen in hospitalized patients, contributing to their morbidity and mortality due to its multiple resistance mechanisms. Therefore, as therapeutic options become restricted, the search for new agents is a priority. Latterly an accelerated increase in frequency of multidrug-resistant clinical strains has severely limited the availability of therapeutic options. Several in vitro and in vitro studies evaluating the efficacy of different antimicrobials agents and development of vaccines against P. aeruginosa have been reported as novel approaches, such as inhibition of virulence factor expression or inhibition of their metabolic pathways.