Dedifferentiated Chondrosarcoma with a High-Grade Mesenchymal Component Mimicking a Gastrointestinal Stromal Tumor

作     者：Toshihiro Akisue Kenta Kishimoto Teruya Kawamoto Hitomi Hara Masahiro Kurosaka 

作者机构：Department of Orthopaedic Surgery Graduate School of Medicine Kobe University Kobe Japan 

出 版 物：《Open Journal of Pathology》 (病理学期刊（英文）)

年 卷 期：2012年第2卷第3期

页      面：90-95页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Dedifferentiated Chondrosarcoma Gastrointestinal Stromal Tumor c-kit Histology Immunohistochemistry 

摘      要：This report presents a dedifferentiated chondrosarcoma with a unique pathologic feature. A 63-year-old man was referred with pain and a soft tissue mass in the left groin. A plain radiograph showed a mineralization in the proximal femur with partially osteolytic foci and an abnormal shadow in the soft tissue. Magnetic resonance imaging scans showed an inhomogeneous lesion with intermediate to partially low signal intensity on T1-weighted image and intermediate to high signal intensity on T2-weighted image. Microscopically, the tumor in the femur is a low-grade chondrosarcoma and the component of soft tissue was a high-grade sarcomatous lesion with an epithelial arrangement of tumor cells. A diffuse immunoreactivity to both vimentin and c-kit (CD117) antibodies was detected in the high-grade component. A dedifferentiated component is similar to those of gastrointestinal stromal tumor (GIST). This is the first case of dedifferentiated chondrosarcoma with a high-grade component mimicking a GIST.