Effects of prepartal oronasal administration of lipopolysaccharide on milk composition and productivity of transition Holstein dairy cows

作     者：Summera Iqbal Qendrim Zebeli Dominik A. Mansmann Suzanna M. Dunn Burim N. Ametaj 

作者机构：Department of Agricultural Food and Nutritional Science University of Alberta Edmonton Canada Institute of Animal Nutrition and Functional Plant Compounds Department for Farm Animals and Veterinary Public Health Vetmeduni Vienna Vienna Austria 

出 版 物：《Open Journal of Animal Sciences》 (动物科学期刊（英文）)

年 卷 期：2013年第3卷第3期

页      面：200-209页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Lipopolysaccharide Oronasal Milk Composition Dairy Cows 

摘      要：The aim of this study was to evaluate the effects of repeated oronasal administration of lipopolysaccharide (LPS) on milk composition and the overall productive performance of dairy cows. One hundred pregnant Holstein dairy cows were randomly assigned to two treatment groups (n = 50). 30 cows out of 100 were selected for intensive sampling (n = 15) starting at 28 d before parturition. Cows were administered orally and nasally with 2 and 1 mL of saline solution, respectively (control), or saline solution containing 3 doses of LPS from Escherichia coli 0111:B4 as follows: 1) 0.01 μg/kg body weight (BW) on d ﹣28, 2) 0.05 μg/kg BW on d ﹣25 and ﹣21, and 3) 0.1 μg/kg BW on d ﹣18 and ﹣14. Daily feed intake and milk production were recorded for each cow during the first 28 d postpartum. Milk samples were obtained once per week and analyzed for various milk components. Overall, results indicated that treatment did not affect feed intake, milk yield, milk efficiency, fat content, fat yield, protein content, protein yield, lactose content, lactose yield, milk urea nitrogen (MUN), total solid contents, fat-corrected milk (FCM), and energy-corrected milk (ECM;P 0.05). However, milk somatic cell count (SCC) tended to be lower in the treated cows (P eek interaction for milk energy (P = 0.03), and tendencies for FCM, ECM, lactose content, and milk efficiency