The Relation between Apolipoprotein E4 Genotype and Vascular Dementia

作     者：Tomader Taha Abdel Rahman Safia Mohamed Shehata 

作者机构：Clinical Pathology Department Ain Shams University Hospitals Cairo Egypt Geriatrics Medicine Department Faculty of Medicine Ain Shams University Cairo Egypt 

出 版 物：《Advances in Aging Research》 (老年问题研究（英文）)

年 卷 期：2014年第3卷第3期

页      面：208-215页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Apolipoprotein E4 Cerebral Infarction Genetics Vascular Dementia 

摘      要：Most studies investigating genetics of dementia have focused on Alzheimer’s disease, but little is known about the genetics of vascular dementia (VD). The aim of this study was to identify the association between Apolipoprotein E4 (Apo E4) genotype and VD in cerebrally infarcted patients. The study was conducted on 100 patients with cerebral infarction: 50 had VD (cases) and 50 didn’t have dementia (controls). Diagnosis of VD was based on Mini-Mental State Examination, Cambridge Cognitive Examination (CAMCOG), the Diagnostic and Statistical Manual of Mental Disorders 4th edition criteria for the diagnosis of VD (DSM-IV), Hachinski Ischemic Score, and computed tomography of the brain (CT brain). Apo E4 allele was assessed through DNA genotyping. The study showed that hypertension (p = 0.027, OR = 4.71), diabetes mellitus (p = 0.003, OR = 6.05) and Apo E4 allele (p = 0.017, OR = 13.39) were the independent risk factors of VD among studied participants. The study concluded that cerebrally infarcted patients with Apo E4 genotype are at high risk of developing VD.