Critical Assessment of the Current WADA Approach for the Detection of 4-Chlorodehydromethyltestosteron
Critical Assessment of the Current WADA Approach for the Detection of 4-Chlorodehydromethyltestosteron作者机构：Institute of Biomedical Chemistry Moscow Russia
出 版 物：《Journal of Analytical Sciences, Methods and Instrumentation》 (分析科学方法和仪器期刊（英文）)
年 卷 期：2016年第6卷第4期
页 面：65-82页
学科分类：07[理学] 0701[理学-数学] 070101[理学-基础数学]
主 题：Anti-Doping Mass Spectrometry Substance Identification Data Analysis 4-Chlorodehydromethyltestosterone Turinabol
摘 要：This paper is focused on application of method for detection of novel metabolites of 4-chlorodehydromethyltestosterone (known as oral turinabol, OT), which were postulated as long-term metabolites. The method started to be applied without rigorous validation, verification and excretion assay assisted as evidences for existence of the declared detectable compounds as true metabolites derived after OT biotransformation. This method has been started to use almost in its original form which arose in 2012 year for the very first time and never been revised and re-confirmed in peer-reviewed journals. Usually WADA encourages accredited laboratories to publish their results of methods development, validation and specific excretion studies in peer-reviewed journals. However, an incorrect method with neglected validation design and implicit data contradictions is currently widely applied. The author of this presented paper was athletes’ representative on repeated occasion and has been provided with several full documentation packages of OT novel metabolites analysis. Thus, the author makes its own conclusion based on its own evidences of that currently employed method and data analysis is exactly the same declared in a wrong way as emerged from the original paper.
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