Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis
Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis作者机构：Department of Medicine and Surgery University of Salerno Salerno Italy Department of Clinical and Translational Medicine Federico II University Napoli Italy IBP CNR Napoli Italy IOS e Coleman Napoli Italy
出 版 物：《Journal of Cancer Therapy》 (癌症治疗（英文）)
年 卷 期：2015年第6卷第2期
页 面：199-212页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Metastasis Angiogenesis miRNA GRKs CaMKs
摘 要：Cancer is a multistep process encompassing the transformation of normal epithelial cells to the stromal invasion and metastasis, with these last considered the final stage of the disease. Tumor invasiveness is based on creation of a specific peri-tumoral environment which on turn depends upon epithelial-stromal interactions, degradation of extracellular matrix and reorganization of fibrillar components. Even though several aspects of the stromal and cellular remodeling have been elucidated and described, such as the epithelial-mesenchymal transition (EMT) and extracellular matrix degradation, all the underlying molecular mechanism are far to be elucidated in their complexity. In this review we focused on new actors such as microRNAs, G protein coupled receptor kinases (GRKs) and Calcium/calmodulin-dependent protein kinase (CaMKs) known to be involved in several important physiological processes like development, cell differentiation and cell signaling, and more recently linked to tumor progression and invasion.
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