The comparison of the efficacy of swine FMD vaccine emulsified with oil adjuvant of ISA 201 VG or ISA 206 VG
The comparison of the efficacy of swine FMD vaccine emulsified with oil adjuvant of ISA 201 VG or ISA 206 VG作者机构：State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Animal Virology of Ministry of Agriculture OIE/National Foot and Mouth Disease reference laboratory of China Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Lanzhou China
出 版 物：《Journal of Biosciences and Medicines》 (生物科学与医学（英文）)
年 卷 期：2013年第1卷第3期
页 面：22-25页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Swine FMD Vaccine Adjuvant ISA 201 ISA 206 Immune Efficacy
摘 要：The Seppic Company developed a new adjuvant Montanide ISA 201 VG, the upgraded version of Montanide ISA 206 VG, which keep the advantage and added some chemical components on the basis of ISA 206 to improve the cellular responses. The aim of the study is to compare the efficacy of swine FMD (foot-and-mouth) vaccine emulsified with oil adjuvant of ISA 201 or ISA 206 respectively. The pigs were vaccinated with FMD vaccine emulsified with inactive FMD type O antigen and adjuvant ISA 201 or ISA 206 respectively, according to 2.0 ml (1/1 dose), 0.67 ml (1/3 dose), 0.22 ml (1/9 dose) to calculate their PD50. The sera were collected from the vaccination of the day 0, 3, 7, 14, 21, 28 and the ELISA FMD type O antibody were detected. Furthermore, the PD50 were calculated after the pigs were challenged with virulent FMDV type O on 28 days post vaccination. The ELISA antibody titers of 201vaccine were significantly higher than that of 206 (except the third time). The fifty percent of protection dose (PD50) of 201 vaccine (PD50 = 15.59) was higher than that of 206 vaccine (PD50 = 10.05). The above data showed that the efficacy of the FMD vaccine emulsified with ISA 201 was better than which with ISA 206.
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