Toward understanding the role of p53 in cardiovascular diseases

作     者：Mohanalatha Chandrasekharan Silvia Vasquez Rajesh Kumar Galimudi Prashanth Suravajhala 

作者机构：*** IKP Knowledge Park Secunderabad India Department of Genetics Osmania University Hyderabad India Instituto Peruano de Energía Nuclear Centro Nuclear RACSO Lima Perú 

出 版 物：《Journal of Biomedical Science and Engineering》 (生物医学工程（英文）)

年 卷 期：2013年第6卷第2期

页      面：209-212页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：TP53 Cardiovascular Disease Protein-Protein Interactions 

摘      要：Tumour suppressor protein 53 (TP53 or simply p53) is a well known protein linked to apoptosis, cell signalling, cascading and several myriad functions in cells. Many diseases are linked to p53 though analysis show only 216 interaction partners. Whether p53 plays an important role in cardiovascular diseases (CVD) remains uncertain. Through this bioinformatical analysis, we propose that p53 might play a major role in CVD whilst being linked to Hypoxia and Lupus. There could be evidence by pull down assay studies. Whether its interactants play a role in CVD remains to be studied using experiments, though the interaction maps show possible affect on other diseases.