Peripheral Analgesic and Anti-Inflammatory Effects of Smilax canariensis in an Animal Model
Peripheral Analgesic and Anti-Inflammatory Effects of Smilax canariensis in an Animal Model作者机构：Unidad de Farmacología y Farmacognosia Sección de Farmacia Universidad de La Laguna San Cristóbal de La Laguna Spain
出 版 物：《Pharmacology & Pharmacy》 (药理与制药（英文）)
年 卷 期：2015年第6卷第8期
页 面：391-400页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Smilax canariensis Smilacaceae Medicinal Plant Folk Medicine Analgesic Activity Anti-Inflammatory Activity
摘 要：Smilax canariensis Brouss. ex Willd. is an endemic plant of the Canary Islands. Its rhizomes, leaves and stems have been traditionally used in Canary folk medicine to treat a wide variety of conditions including pain. Our objective is to investigate the analgesic and anti-inflammatory activities of different extracts of S. canariensis in Swiss mice, using established biological models for pain and inflammation, such as phenylquinone writhing test, formalin test, tail-flick test and mouse paw edema induced by carrageenan. Oral administration of S. canariensis extracts significantly reduce writhing episodes evoked by phenylquinone injection in a dose-dependent manner;and higher doses result in a reduction of pain similar to or higher than that of the reference drug piroxicam (59.56%;p 0.01). The extracts also cause a marked dose-dependent inhibition of for-malin-induced pain in the second phase but only minimal inhibition of tail-flick behavior, suggesting that S. canariensis is not a centrally acting analgesic. Finally, in the carrageenan-induced hind paw edema model, the extracts show a moderate anti-inflammatory effect, the most active being the ethyl acetate fraction at 200 mg/kg p.o. (33.33%;p 0.05). Our results suggest that S. canariensis extracts have clear dose-dependent peripheral analgesic effects, which lends support to the traditional use of this medicinal plant to treat pain associated with inflammatory or other processes.
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