Use of ebselen as a neuroprotective agent in rat spinal cord subjected to traumatic injury

作     者：Wojciech ?lusarczyk Edyta Olakowska Magdalena Larysz-Brysz Izabella Woszczycka-Korczyńska Daria Gendosz de Carrillo W?adys?aw P.W?glarz Joanna Lewin-Kowalik Wies?aw Marcol 

作者机构：Department of PhysiologyMedical University of Silesia Institute of Nuclear PhysicsPolish Academy of Sciences 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2019年第14卷第7期

页      面：1255-1261页

核心收录：

学科分类：10[医学] 

主　　题：ebselen antioxidant neuroprotection neuroregeneration spinal cord injury spinal cord repair functional recovery 

摘      要：Spinal cord injury(SCI) causes disturbances of motor *** radicals have been shown to be essential for the development of spinal cord *** some progress,until now no effective pharmacological therapies against SCI have been *** purpose of our experiment was to investigate the neuroprotective effects of ebselen on experimental ***-two rats subjected to SCI were randomly subjected to SCI with no further treatment(n = 10) or intragastric administration of ebselen(10 mg/kg) immediately and 24 hours after *** changes were assessed using the Basso,Beattie,and Bresnahan locomotor scale and footprint test during 12 weeks after *** and immunohistochemical analyses of spinal cords and brains were performed at 12 weeks after *** resonance imaging analysis of spinal cords was also performed at 12 weeks after *** treated with ebselen presented only limited neurobehavioral progress as well as reduced spinal cord injuries compared with the control group,namely length of lesions(cysts/scars)visualized histopathologically in the spinal cord sections was less but cavity area was very *** same pattern was found in T2-weighted magnetic resonance images(cavities) and diffusion-weighted images(scars).The number of FluoroGold retrogradely labeled neurons in brain stem and motor cortex was several-fold higher in ebselen-treated rats than in the control *** findings suggest that ebselen has only limited neuroprotective effects on injured spinal *** exprimental procedures were approved by the Local Animal Ethics Committee for Experiments on Animals in Katowice(Katowice,Poland)(approval No.19/2009).