Osteoblastoma of the mandible: a case report with immunohistochemical evaluation

作     者：Evanthia Chrysomali Ourania Schoinohoriti Nadia Theologie-Lygidakis Lambros Goutzanis Ioannis Iatrou 

作者机构：不详 

出 版 物：《Open Journal of Stomatology》 (口腔学期刊（英文）)

年 卷 期：2011年第1卷第4期

页      面：207-211页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Osteoblastoma Mandible Reconstruction Immunohistochemistry Ki-67 Bcl-2 p53 Bone Tumors 

摘      要：Background: Osteoblastoma, a rare osteoblastic tumor, constitutes approximately 1% of all primary bone tu- mors. Aim: The purpose of this report is to present an osteoblastoma of the mandible, with particular emphasis on the differential diagnosis of this rare tu- mor. Methods-Results: the lesion showed osteoblast- like cells, stromal cells, osteoclast-like cells and inter- lacing trabeculae of osteoid. Because of the high cel- lularity of the tumor, immunohistochemical analysis was performed using the cell proliferation marker Ki-67, the p53 and the anti-apoptotic protein Bcl-2. The lesion demonstrated low to moderate prolifera- tive activity and no immunoreactivity was detected for p53. An interesting finding was the Bcl-2 expres- sion by the multinucleated osteoclast-like giant cells, in contrast to the lack of Bcl-2 expression from osteo- blast-like and stromal tumor cells. Conclusion: To our knowledge the Bcl-2 expression has not yet been in- vestigated in benign or malignant osteoblastic tumors. This finding may be related to the molecular mecha- nisms regulating the apoptosis of osteoclast-like tu- mor cells or their function.