Application of a novel porous tantalum implant in rabbit anterior lumbar spine fusion model:in vitro and in vivo experiments
Application of a novel porous tantalum implant in rabbit anterior lumbar spine fusion model: in vitro and in vivo experiments作者机构：Department of OrthopedicThe Third Affiliated Hospital of Southern Medical UniversityGuangzhouGuangdong 510630China Academy of Orthopaedics of Guangdong ProvinceGuangzhouGuangdong 510630China Department of ArthroplastyNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Ning Xia Orient Tantalum Industry Co.LtdShizuishanNingxia 753000China Department of PhysicsUniversity of OuluOulu FIN-90014Finland
出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)
年 卷 期：2019年第132卷第1期
页 面：51-62页
核心收录：
基 金：supported by a grant from Guangdong Province Science and Technology Plan Project
主 题：Porous tantalum anterior lumbar interbody fusion bone ingrowth chemical vapor deposition three-dimensional knitted framework
摘 要：Background Some porous materials have been developed to enhance biologic fusion of the implants to bone in spine fusion ***,there are several inherent *** this study,a novel biomedical porous tantalum was applied to in vitro and in vivo experiments to test its biocompatibility and *** Bone marrow-derived mesenchymal stem cells (BMSCs) were cultured on porous tantalum *** electron microscope (SEM) and Cell Counting Kit-8 assay were used to evaluate the cell toxicity and ***-four rabbits were performed discectomy only (control group),discectomy with autologous bone implanted (autograft group),and discectomy with porous tantalum implanted (tantalum group) at 3 levels:L3–L4,L4–L5,and L5–L6 in random *** the 24 rabbits were randomly sacrificed at the different post-operative times (2,4,6,and 12 months;n = 6 at each time point).Histologic examination and micro-computed tomography scans were done to evaluate the fusion *** of fusion index scores between groups was analyzed using one-way analysis of *** comparisons of numerical variables between groups were made by Student t *** All rabbits survived and recovered without any symptoms of nerve *** fusion index scores at 12 months post-operatively between autograft and tantalum groups showed no significant difference (2.89 ± 0.32 vs.2.83 ± 0.38, F= 244.60, P = 0.709).Cell Counting Kit-8 assay showed no significant difference of absorbance values between the leaching liquor group and control group (1.25 ± 0.06 vs.1.23 ± 0.04, t = –0.644, P = 0.545),which indicated the BMSC proliferation without *** images showed that these cells had irregular shapes with long spindles adhered to the surface of tantalum *** implant degradation,wear debris,or osteolysis was *** results showed solid fusion in the porous tantalum and autologous bone implanted intervertebral spaces
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