Effects of electroacupuncture on microcirculatory blood flow and glucose transporter function in the hippocampus

作     者：Lu, Yan Han, Bingbing Wang, Shijun 

作者机构：Shandong Univ Tradit Chinese Med Dept Expt Acupuncturol Acupuncture & Moxibust Coll Jinan 250355 Shandong Peoples R China Shandong Univ Tradit Chinese Med Microcirculat Lab Basic Med Coll Jinan 250355 Shandong Peoples R China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第3期

页      面：200-205页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 1002[医学-临床医学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 071002[理学-动物学] 

基　　金：the National Natural Science Foundation of China No. 30672717 

主　　题：Electroacupuncture Neiguan （PC 6） focal cerebral ischemia microvascularendothelial cells glucose transporter 1 cerebral blood flow CA1 region neural regeneration 

摘      要：Nerve cell metabolism in post brain ischemia depends on increased microcirculation perfusion and transport function of microvascular endothelial cells. In the present study, a rat model of middle cerebral artery occlusion was established to investigate the influence of electroacupuncture （EA） on hippocampal CA1 cerebral blood flow and glucose transporter 1 （GLUT1） expression in the microvascular endothelial cells. Following EA at Neiguan （PC 6）, the cerebral blood flow in the ischemic hippocampal CA1 region was significantly elevated, the number and microvascular integrated absorbance of the GLUTl-positive cells were significantly increased, nerve cell damage was ameliorated, and GLUT1 protein expression in the ischemic hippocampus was significantly increased. Results demonstrate that EA increased the cerebral blood flow of the hippocampal CA1 region and improved the glucose transport function, thereby attenuating neuronal injuries.