Human interleukin-2 gene transfer into ovarian cancer cell lines SKOV3, decreased the proliferation, tumorigenesis and enhanced the immunity of the tumor cells
Human interleukin-2 gene transfer into ovarian cancer cell lines SKOV3, decreased the proliferation, tumorigenesis and enhanced the immunity of the tumor cells出 版 物：《中国实验血液学杂志》 (Journal of Experimental Hematology)
年 卷 期：1997年第5卷第3期
页 面：308-308页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：interleukin immunity tumorigenesis encoding clone morphologic parental collagen vaccine lymphocyte
摘 要：To study the effects of human interleukin-2 genetransfer on the morphology, proliferation, tumori-genesis, immunity, and oncogenes expression of tumorcells, the gene encoding human interleukin-2 (IL-2) wasintroduced via retroviral vectors pLXSN into ovariancancer cell lines SKOV3. A resistant clone with high IL-2activity (318 U/10~6cell/24 hours) in the culturesupernatants was cloned. The hIL-2 mRNA was detectedwith RT-PCR in SKOV3/IL2 cells. The IL2 secretinghas persisted for 23 weeks with 38 passanges. The
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