Adoptive transfer of IL-10^(+) regulatory B cells decreases myeloid-derived macrophages in the central nervous system in a transgenic amyotrophic lateral sclerosis model

作     者：Andrea Pennati Seneshaw Asress Jonathan D Glass Jacques Galipeau 

作者机构：Department of MedicineUniversity of Wisconsin School of Medicine and Public Health and University of Wisconsin Carbone Cancer CenterMadisonWI 53706USA Department of NeurologyEmory UniversityAtlantaGA 30322USA 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2018年第15卷第7期

页      面：727-730页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported in part by R01AI093881(JG)and by a gift from Above&Beyond LLC 

主　　题：sustained sclerosis autoimmune 

摘      要：I mmunosuppressive therapies have meaningful effects on the treatment of multiple sclerosis(MS),a classical inflammatory autoimmune disease of the central nervous system.1 In mice with experimental autoimmune encephalomyelitis(EAE),a murine model of human MS,we showed that an adoptive transfer of GM-CSF and Interleukin-15 Fusion Transgene(GIFT15)-derived regulatory B cells(GIFT15 Bregs)sustained a durable remission of the disease.2,3 These regulatory B cells require the expression of MHC class II and IL-10 for suppressive activity.