Recent advances in the chemical synthesis and semi-synthesis of poly-ubiquitin-based proteins and probes
Recent advances in the chemical synthesis and semi-synthesis of poly-ubiquitin-based proteins and probes作者机构：Department of Medicinal Chemistry School of Pharmacy Qingdao University Institute of Innovative Drugs Qingdao University School of Life Sciences University of Science and Technology of China State Key Laboratory Base for Eco-Chemical Engineering in College of Chemical Engineering Qingdao University of Science and Technology
出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)
年 卷 期：2019年第62卷第3期
页 面：299-312页
核心收录：
基 金：supported by the National Natural Science Foundation of China (21807063, 91753120, U1732161, 81503094) the start-up grant from Qingdao University (41118010086) the China Postdoctoral Science Foundation (2016 M600524)
主 题：ubiquitination poly-ubiquitin chains poly-ubiquitin-based proteins poly-ubiquitin-based probes chemical protein synthesis
摘 要：Ubiquitination, a key and extensive posttranslational modification of proteins, has profound effects on a variety of physiological and pathological processes. The inherent complexity of ubiquitin conjugates makes it highly challenging to study the functional and structural mechanisms of ubiquitination. To address these challenges, accesses to sufficient poly-ubiquitin chains or ubiquitinated proteins are urgently needed. Over the last decade, synthetic protein chemists have developed several novel peptide ligation methods for the preparation of ubiquitin conjugates with precise control over the atomic structure. In this review, we summarize the recent breakthroughs and potential challenges in the chemical synthesis and semi-synthesis of ubiquitin conjugates with respect to the preparation of poly-ubiquitin-based proteins and ubiquitin-based probes.
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