Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility

作     者：Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun 

作者机构：Center for Reproductive MedicineDepartment of Obstetrics and Gynecologythe Affiliated Drum Tower Hospital of Nanjing University Medieal SchoolNanjing 210008China Clinical Center for Stem Cell Researchthe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Obstetrics and Gynecologythe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China State Key Laboratory of Molecular Development BiologyInstitute of Genetics and Developmental BiologyChinese Academy of Sciences Beijing 100190China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2018年第61卷第12期

页      面：1554-1565页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

基　　金：supported by Strategic Priority Research Program of the Chinese Academy of Sciences (XDA01030501 to Haixiang Sun) National Natural Science Foundation of China (31571189, 81571391, 30900847 to Lijun Ding) Jiangsu Provincial Medical Youth Talent (QNRC2016006) Nanjing Medical Science Development Project (JQX14004, ZKX16042) 

主　　题：premature ovarian failure collagen scaffold UC-MSCs primordial follicle activation granulosa cells FOXO3a FOXO1 

摘      要：Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF.