Nanotexture optimization by oxygen plasma of mesoporous silica thin film for enrichment of low molecular weight peptides captured from human serum

作     者：Louis BROUSSEAU Ali BOUAMRANI Mauro FERRARI 

作者机构：Department of Nanomedicine and Biomedical EngineeringThe University of Texas Health Science Center at Houston 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2010年第53卷第11期

页      面：2257-2264页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported by the following grants issued in the US:State of Texas's Emerging Technology Fund,National Institute of Health (NIH) (R21/R33CA122864, R01CA128797) National Aeronautics and Space Administration (NASA) (NNJ06HE06A) Department of Defense (DoD) Breast Cancer Research Program Innovator Award (W81XWH-09- 1-0212) 

主　　题：mesoporous silica thin film oxygen plasma low molecular weight proteome 

摘      要：The optimization of mesoporous silica thin films by nanotexturing using oxygen plasma versus thermal oxidation was *** in oxygen plasma provides superior control over pore formation with regard to the pore surface and higher fidelity to the structure of the polymer *** resulting porous film offers an ideal substrate for the selective partitioning of peptides from complex *** improved chemico-physical characteristics of porous thin films(pore size distribution,nanostructure,surface properties and pore connectivity) were systematically characterized with XRD,Ellipsometry,FTIR,TEM and N2 adsorption/desorption *** enrichment of low molecular weight proteins captured from human serum on mesoporous silica thin films fabricated by both methodologies was investigated by comparison of their MALDI-TOF MS *** novel on-chip fractionation technology offers advantages in recovering the low molecular weight peptides from human serum,which has been recognized as an informative resource for early diagnosis of cancer and other diseases.