Concentration change of TGF-β1 in aqueous humor of rabbits

作     者：Xiao-Yi Yu Wei Wu Xiao-He Lu 

作者机构：Department of OphthalmologySouthern Medical University Department of OphthalmologyWuyi Traditional Chinese Medicine Hospital 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2014年第7卷第3期

页      面：241-243页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

基　　金：supported by National Natural Science Foundation Project(No.81371067) 

主　　题：TGF-β1 eye drops Aqueous humor Transforming growth factor 

摘      要：Objective:To observe the influence of the the transforming growth factorβ1(TGF-β1)eve drops on rabbit aqueous humor TGF-β1 concentration,and to analyze the best drug ***:A total of 30 New Zealand white rabbits were randomly divided into5 groups with 6 in *** in control group had PBS eye drops,group A,B.C,D adopted TGF-β1 eye drops at 0.5,1.***.2.0.4.0 mg/L,respectively.4 times a *** humor of right eye was extracted 1 week after administration lo delect concentration changes of TGF-β1 by ELISA;rabbits in fpur hroups adopted 2.0 mg/L eye drops to left eyes 4 times a day,0.2 mL aqueous humor was extracted left eye at the scheduled time point 0,30 min,2 h,4 h,24 h for testing,the slit lamp was used to observe the cornea,chamber and ***:No obvious pathological changes in conjunctiva,cornea,rabbit conjunctival,anterior chamber,and the lens was *** of TGF-β1 in rabbit aqueous humor in C.D group was significantly higher than the control group(P0.05).Conclusions:TGF-β1 eye drops at 2.0 mg/L.4.0 mg/L can significantly increase concentration of TGF-β1 in rabbit aqueous humor,withe good ocular surfac permeability.