The effects of Xingnao Jieyu capsules on post-stroke depression are similar to those of fluoxetine

作     者：Yongmei Yan Wentao Fan Li Liu Ru Yang Wenjia Yang 

作者机构：Department of Encephalopathy Affiliated Hospital of Shaanxi University of Chinese Medicine Encephalopathology Key Subject of Traditional Chinese Medicine State Administration of Traditional Chinese Medicine of the People's Republic of China Research Room of Traditional Chinese Medicine Internal Medicine Shaanxi University of Chinese Medicine 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2013年第8卷第19期

页      面：1765-1772页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：funded by the Key Science and Technology Project of Shaanxi Provincial "13115"Technology Innovation Engineering No.2010ZDKG-65 

主　　题：neural regeneration traditional Chinese medicine Xingnao Jieyu capsule stroke post-stroke de-pression synapsin neurologic impairment chronic stress depression hippocampus grants-supported paper neuroregeneration 

摘      要：The Xingnao Jieyu capsule has been shown to effectively relieve neurologic impairments and les- sen depression. It remains poorly understood whether this capsule can be used to treat post-stroke depression. Thus, in the present study, we established a rat model of post-stroke depression using left middle cerebral artery occlusions in combination of chronic unpredictable stress and solitary housing during development. Experimental rats received intragastric perfusion with 0.82, 0.41, and 0.20 g/kg Xingnao Jieyu capsules separately dissolved in 2 mL distilled water. Fluoxetine served as a positive control. The treatment was conducted over 28 days. Sugar water consumption test, open-field test, real-time fluorescent quantitative PCR and immunohistochemical staining results demonstrated that intragastric perfusion with various doses of Xingnao Jieyu capsules increased sugar water consumption, voluntary behaviors and synaptotagmin mRNA and protein expression in rats with post-stroke depression. These therapeutic effects were similar to those of fluoxetine. These results indicate that Xingnao Jieyu capsules upregulate synaptotagmin expression in hip pocampi of rats with post-stroke depression, and exert antidepressant effects.