Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application

作     者：Sihui Ouyang Qianli Huang Yong Liu Zhengxiao Ouyang Luxin Liang 

作者机构：State Key Lab of Powder MetallurgyCentral South UniversityChangsha410083PR China Department of OrthopedicsThe Second Xiangya HospitalCentral South UniversityChangshaHunanPR China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2019年第4卷第1期

页      面：37-42页

核心收录：

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：the support from the National Natural Science Funds for Distinguished Young Scholar of China(51625404) China Postdoctoral Science Foundation(2018M630909) 

主　　题：Powder metallurgy Composites Osteoconduction Osseointegration 

摘      要：In this work,TieMg metal-metal composites(MMCs)were successfully fabricated by spark plasma sintering(SPS).In vitro,the proliferation and differentiation of SaOS-2 cells in response to TieMg metal-metal composites(MMCs)were *** vivo,a rat model with femur condyle defect was employed,and TieMg MMCs implants were embedded into the femur *** showed that TieMg MMCs exhibited enhanced cytocompatibility to SaOS-2 cells than pure *** micro-computed tomography(Micro-CT)results showed that the volume of bone trabecula was significantly more abundant around TieMg implants than around Ti implants,indicating that more active new-bone formed around TieMg MMCs ***-eosin(H&E)staining analysis revealed significantly greater osteointegration around TieMg implants than that around Ti implants.