Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum

作     者：LIN Peng-Cheng JI Lin-Lin ZHONG Xiang-Jian LI Jin-Jie WANG Xin SHANG Xiao-Ya LIN Sheng LIN Peng-Cheng;JI Lin-Lin;ZHONG Xiang-Jian;LI Jin-Jie;WANG Xin;SHANG Xiao-Ya;LIN Sheng

作者机构：College of Pharmaceutical SciencesQinghai University for Nationalities Beiijing Key Laboratory of Bioactive Substances and Functional FoodsBeijing Union University State Key Laboratory of Bioactive Substance and Function of Natural MedicinesInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2019年第17卷第1期

页      面：22-26页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the Key projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee(No.KZ201811417049) the National Natural Science Foundation of China(Nos.81522050,81773589 and 81760783) the Science and Technology program of Qinghai(No.2018-ZJ-739) the Scientific Research Common Program of Beijing Municipal Commission of Education(No.KM201811417008) 

主　　题：Cirsium setosum Taraxastane-type triterpenoid TNF-α secretion inhibitory activity Cytotoxicity 

摘      要：Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol(1) and 22α-hydroxy-20-taraxasten-30β, 30-triol(2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the TNF-α secretion inhibitory activity assay, compounds 1 and 2 were active with the IC50 of 2.6 and 3.8 μmol·L-1, respectively. In addition, compounds 1 and 2 showed moderately selective cytotoxicity against the human ovarian cancer(A2780) and colon cancer(HCT-8) cell lines.