Discoveries and functions of virus-encoded MicroRNAs

作     者：JIA WanZhong LI Zhi LUN ZhaoRong 

作者机构：Center for Parasitic Organisms State Key Laboratory of Biocontrol School of Life Sciences and Key Laboratory of Tropical Diseases Control of the Ministry of Education Zhongshan Medical College Sun Yat-Sen (Zhongshan) University Guangzhou 510275 China Key Laboratory of Veterinary Parasitology of Gansu Province State Key Laboratory of Veterinary Etiological Biology Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Lanzhou 730046 China 

出 版 物：《Chinese Science Bulletin》 (中国科学通报)

年 卷 期：2008年第53卷第2期

页      面：169-177页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：the Ministry of Education of China (Grant No. IRT0447) 

主　　题：RNA 病毒编码 基因调节 函数 

摘      要：Virus-encoded microRNAs (miRNAs) are a new kind of miRNAs that regulate the expression of target gene in host cells or viruses through inducing cleavage of mRNA, repressing translation, etc., and change the processes of host cells or replicate viruses to escape or resist immune surveillance of host and protect viruses themselves. It has become a hot topic to discover viral genes encoding miRNAs and their target genes, and to identify their functions. This review provides background information on the history of virally encoded miRNAs including their genomic distribution, functions and mechanisms. In addition, we discuss the similarities and differences between virus- and host-encoded miRNAs, the future directions of researches in viral miRNAs and their applications in diseases control and therapy.