Inhibition of mouse tumors by heavy ion irradiation

作     者：LI Wen-Jian WEI Zeng-Quan LI Qiang ZHOU Guang-Ming DANG Bing-Rong XIE Hong-Mei WANG Ju-Fang (Institute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 730000) ZHANG Xiao-Wen GUO Hong-Yun (Gansu Academy of Medical Sciences, Lanzhou 730050) 

作者机构：Institute of Modern Physics the Chinese Academy of Sciences Lanzhou 730000 Gansu Academy of Medical Sciences Lanzhou 730050 

出 版 物：《Nuclear Science and Techniques》 (核技术（英文）)

年 卷 期：2000年第11卷第1期

页      面：22-26页

核心收录：

学科分类：071011[理学-生物物理学] 0710[理学-生物学] 07[理学] 

基　　金：President Special Foundation of the Chinese Academy of Sciences 

主　　题：重离子照射 鼠 动物实验 病理学说 肿瘤 辐射疗法 抑制作用 

摘      要：Inhibition effects, control probabilities and pathology tissue changes of mouse transplanted tumors S180 after irradiation with 50 MeVu 12C6+ ions are reported. Doses of single irradiation were 0.5, 1, 2, 5, 10, 20, 40 Gy, respectivelyl at a dose rate of 3 Gy/min. Observing time was 24 days. The results show that each group had significant inhibition action on S180 tumors and all inhibitory probabilities were more than 90%; the initial time of inducing tumor inhibition effects were within one week in high dose groups （20, 40 Gy）, and after two weeks in medium dose groups （5, 10 Gy） and low dose groups （0.5, 1, 2 Gy）; also, inhibitory effects in high dose groups were obviously greater than other groups （p 0.05）; tumor control probabilities were different in each group) those in high dose groups （20, 40 Gy） were higher and TCD50 （50% tumor control dose） was 20Gy; the results for curing tumors are different in different doses; pathology inspection presented here were tumor tissue necrosis and degeneration in each dose group and they depended on doses.