HGF/SF-Met signaling in tumor progression

作     者：George F. VANDE WOUDE 

作者机构：N.E Grand Rapids Laboratory of Molecular Oncology Van Andel Research Institute #333 Bostwick Ave. USA MI 49503 

出 版 物：《Cell Research》 (细胞研究(英文版))

年 卷 期：2005年第15卷第1期

页      面：49-51页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：HGF/SF-Met signaling tumor progression. 

摘      要：Tumor progression is a multi-step process that requires a sequential selection of specific malignant phenotypes. Met activation may induce different phenotypes depending on tumor stage: inducing proliferation and angiogenesis in pri- mary tumors, stimulating motility to form micrometastases, and regaining the proliferation phenotype to form overt metastases. To study how HGF/SF-induced proliferative phenotypes switch to the invasive phenotype is important for understanding the mechanism of tumor progression and will provide an attractive target for cancer intervention and therapy.