Enhancing the stability of astaxanthin by encapsulation in poly (1-lactic acid) microspheres using a supercritical anti-solvent process
作者机构：School of Chemistry and Chemical Engineering South China University of Technology Guangzhou 510640 China
出 版 物：《Particuology》 (颗粒学报（英文版）)
年 卷 期：2019年第17卷第3期
页 面：54-62页
核心收录：
学科分类：0817[工学-化学工程与技术] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学] 0801[工学-力学（可授工学、理学学位）]
基 金：Financial support from the National Natural Science Foundation of China (21476086,21776102) China Postdoctoral Science Foundation (No. 2017M612663) is greatly appreciated
主 题：Astaxanthin Poly (1-lactic acid) Encapsulation Supercritical anti-solvent Stability
摘 要：To improve the physicochemical properties of astaxanthin, it was encapsulated in poly (1-lactic acid)(PLLA) using a supercritical anti-solvent (SAS) process with dichloromethane/acetone mixture as the solvent, and supercritical CO2 as the anti-solvent. The effects of altering five SAS operating cond让ions, solvent ratio, temperature, pressure, concentration of carrier, and flow rate, on the microstructure of particles were investigated using an orthogonal experimental design. Under the optimal conditions, astaxanthin/PLLA particles were produced with an encapsulation efficiency of 91.5% and a mean particle size of 954.6 nm. SEM images showed that most astaxanthin/PLLA particles were uniform microspheres. FT-IR spectra showed that the chemical structure of astaxanthin was unchanged by the SAS process. The results of chromatic difference, X-ray diffraction, thermogravimetric, and differential scanning calorimetry analyses showed that astaxanthin had been encapsulated in the PLLA matrix in an amorphous state. Overall, astaxanthin/PLLA microspheres greatly enhanced the stability of astaxanthin during storage, and the levels of residual solvents were far lower than the ICH lim让s. This means that astaxanthin/PLLA microspheres prepared using SAS show great potential for use in many food, cosmetic, and pharmaceutical formulations.
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