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Synthesis of amphiphilic poly(fluorene) derivatives for selective imaging of Staphylococcus aureus

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Science Bulletin 2018年第14期63卷 900-906页

作者： Ping He Fengting Lv Libing Liu Shu Wang Key Laboratory of Organic Solids Institute of ChemistryChinese Academy of Sciences Beijing 100190 China College of Chemistry University of Chinese Academy of Sciences Beijing 100049 China

Three amphiphilic poly(fluorene-co-phenylene) derivatives with different side chains(PFP-1, PFP-2, PFP-3) were designed and synthesized for exploring their detection and imaging of pathogens. Upon incubation with six kinds of different pathogens, it was found the three polymers could selectively interact with Staphylococcus aureus(S. aureus). Their selective imaging towards S. aureus were thus realized. The selective imaging towards S. aureus was also confirmed even under the blend of microbes. PFP-3 shows stronger fluorescence imaging signal than PFP-1 and PFP-2. Zeta potential and isothermal titration microcalorimetry(ITC) tests demonstrated that both electrostatic interactions and hydrophobic interactions played important roles in the binding between PFPs and pathogens. Thus, amphiphilic PFP-3 exhibits great potential for specific imaging of S. aureus in a simple and rapid manner.

关键词：成像信号 poly 葡萄球菌衍生物合成病原体相互作用聚合物

polymetal同意出售37亿美元俄罗斯资产

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中国贵金属 2024年第3期 50-50页

贵金属生产商jpolymetal International表示,已同意以约37亿美元的价格将其俄罗斯资产出售给西伯利亚一家金矿商。同时表示,受东欧冲突影响,该交易被迫低价成交。

关键词：资产出售西伯利亚同意 poly 俄罗斯生产商

Enhanced piezo-response in copper halide perovskites based PVDF composite films

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Science Bulletin 2018年第19期63卷 1254-1259页

作者： Sheng Huang Gang Tang Hailong Huang Xian-gang Wu Puming Zhou Lin Zou Lei Xie Jianming Deng Xueyun Wang Haizheng Zhong Jiawang Hong Beijing Key Laboratory of Nanophotonics and Ultrafine Optoelectronic Systems School of Materials Science & Engineering Beijing Institute of Technology Beijing 100081. China School of Aerospace Engineering Beijing Institute of Technology Beijing 100081 China The 48th Research Institute China Electronics Technology Group Corporation Changsha 410111 China Key Laboratory of Neutron Physics and Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics Mianyang 621999 China

In-situ fabricated perovskite nanocrystals in polymeric matrix provide new generation composite materials for plenty of cutting edge technology. In this work, we report the in-situ fabrication of copper halide perovskite(MA_2CuCl_4, MA:CH_3NH_3^+) embedded poly(vinylidene fluoride)(PVDF) composite films. The optimized MA_2CuCl_4/PVDF composite films exhibit greatly enhanced piezo-response in comparasion with pure PVDF films. The enhancements were invesitgated and explained by applying piezo-response force microscopy(PFM) measurements and density functional theory(DFT) caculations. We proposed that the high piezoelectric properties of MA_2CuCl_4/PVDF composite films could be related to the large Cu off-centering displacement, the strong interactions between MA_2CuCl_4 and PVDF as well as large stress concentration around the MA_2CuCl_4 particles in the films. These piezoelectric composite films are expected to be suitable functional materials for flexible and/or wearable piezoelectrics.

关键词： PVDF 反应力卤化物电影合成铜 poly 压力集中

Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes

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Science Bulletin 2018年第2期63卷 92-100页

作者： Mengyu Guo Guoqiang Zhou Zhu Liu Jing Liu Jinglong Tang Yating Xiao Wenshi Xu Ying Liu Chunying Chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190 China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education College of Chemistry and Environmental Science Hebei University Baoding 050011 China University of Chinese Academy Sciences Beijing 100049 China

Doxorubicin(DOX) is widely used in cancer therapy. However, its application is sometimes limited by its adverse cardiotoxicity and delivery pathways. In our study, we prepared a topical implantable delivery device for controlled drug release and site-specific treatment. The core region consisted of poly(lactic co-glycolic acid) and poly-caprolactone, whereas the shell region was composed of cross-linked gelatin.DOX was enclosed in the core region of a core-shell nanofiber obtained by electrospinning. This implantable delivery device was implanted on the top of the melanoma in a mouse model, which had shown a DOX-controlled release profile with sustained and sufficient local concentration against melanoma growth in mice with negligible side effects. Compared with the traditional intravenous administration,the implantable device allows precisely localized treatment and therefore can reduce the dose, decrease the injection frequency, and ensure antitumor efficacy associated with lower side effects to normal tissues. Using a coaxial electrospinning process, it is promising to deliver different hydrophobic or hydrophilic drugs for direct tumor site-specific therapy without large systemic doses and minimized systemic toxicity.

关键词：癌症治疗地点装载 poly 副作用植入膜影片

Functionalization of small black phosphorus nanoparticles for targeted imaging and photothermal therapy of cancer

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Science Bulletin 2018年第14期63卷 917-924页

作者： Lijuan Deng Yifan Xu Caixia Sun Baofeng Yun Qiao Sun Chongjun Zhao Zhen Li Key Laboratory for Ultrafine Materials of Ministry of Education. Shanghai Key Laboratory of Advanced polymeric Materials School of Material Science and Engineering East China University of Science and Technology Shanghai 200237 China Center for Molecular imaging and Nuclear Medicine State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (PAD-X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University Suzhou 215123 China College of Textile and Clothing Engineering Soochow University Suzhou 215123 China

Black phosphorus(BP) nanomaterials have attracted extensive attention due to their unique physical,chemical, and biological properties. In this study, small BP nanoparticles were synthesized and modified with dextran and poly(ethyleneimine) for functionalization with folic acid and cyanine 7. The functionalized BP nanoparticles exhibit excellent biocompatibility, stability, and near infrared optical properties for targeted imaging of tumors through photoacoustic imaging and near-infrared fluorescence imaging.They also display high photothermal conversion efficiency for photothermal therapy of cancer. This work demonstrates the potential of functionalized small BP nanoparticles as an emerging nanotheranostic agent for the diagnosis and treatment of cancer.

关键词：荧光成像癌症治疗指向磷近红外线 poly 变换效率

Ion exchange membranes from poly(2,6-dimethyl-1,4-phenylene oxide) and related applications

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Science China Chemistry 2018年第9期61卷 1062-1087页

作者： Jiahui Zhou Peipei Zuo Yahua Liu Zhengjin Yang Tongwen Xu CAS Key Laboratory of Soft Matter Chemistry Collaborative Innovation Center of Chemistry for Energy Materials School of Chemistry and Materials Science University of Science and Technology of China

Ion exchange membranes(IEMs) play a significant role in fields of energy and environment, for instance fuel cells, diffusion dialysis, electrodialysis, etc. The limited choice of commercially available IEMs has produced a strong demand of fabricating IEMs with improved properties via facile synthetic strategies over the past two decades. poly(phenylene oxide)(PPO) is considered as a promising polymeric material for constructing practical IEMs, due to its advantages of good physicochemical properties, low manufacturing cost and easy post functionalization. In this review, we present the accumulated efforts in synthetic strategies towards diverse types of PPO-based IEMs. Relation between polymer structures and the resulted features is discussed in detail. Besides, applying IEMs from PPO and its derivatives in fuel cell, diffusion dialysis and electrodialysis is summarized and commented.

关键词：离子交换膜氧化物 poly 应用生产费用 IEM 聚合物结构 poly

Preparation of poly(lactide-co-glycolide)microspheres and evaluation of pharmacokinetics and tissue distribution of BDMC-PLGA-MS in rats

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Asian Journal of Pharmaceutical Sciences 2018年第1期13卷 82-90页

作者： Guozhuan Li Liang Yao Jing Li Xiaoyan Qin Zhen Qiu Weidong Chen Anhui University of Chinese Medicine Hefei First People's Hospital

The aim of the present study was to develop a novel long-acting poly(lactic-co-glycolic acid)(PLGA)-based microspheres formulation of Bisdemethoxycurcum(BDMC) by emulsionsolvent evaporation method. Meanwhile, the effects of the volume ratio of the dispersed phase and continuous phase, the concentration of PLGA and PVA, the theoretical drug loading and stirring speed were investigated. The mean diameter of the microspheres was 8.5 μm and the size distribution was narrow. The encapsulation efficiency(EE) and drug loading efficiency(DLE) of BDME loaded PLGA microspheres(BDMC-PLGA-MS) was 94.18% and 8.14%,respectively. In an in vitro study of drug release, it can be concluded that the BDMC-PLGAMS exhibited sustained and long-term release properties for 96 h. Stability studies suggested that the microspheres we prepared had a very good stability. Furthermore, the results of an in vivo study indicated that the BDMC-PLGA-MS had sustained release effect and was mainly distributed in the lung tissue, and less distribution in other tissues, which indicated that microspheres could be an effective parenteral carrier for the delivery of BDMC in lung cancer treatment.

关键词： Bisdemethoxycurcumin Microsphere poly (lactic-co-glycolic acid) Solvent evaporation method Pharmacokinetics

Insight into fouling behavior of poly(vinylidene fluoride)(PVDF)hollow fiber membranes caused by dextran with different pore size distributions

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Chinese Journal of Chemical Engineering 2018年第2期26卷 268-277页

作者： Kailiang Zeng Jie Zhou Zhaoliang Cui Yue Zhou Chuan Shi Xiaozu Wang Liyue Zhou Xiaobin Ding Zhaohui Wang Enrico Drioli State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 210009China National Engineering Research Center for Speical Separation Membrane Nanjing Tech UniversityNanjing 210009China Nanjing Jiuying Membrane Technologies Co. Ltd.Nanjing 211899China Research Institute on Membrane Technology ITM-CNRVia Pietro Bucci 17/CRende 87036Italy

Membrane fouling is the key problem that occurs in membrane process for water treatment. However, how membrane microstructure influences the fouling behavior is still not clear. In this study, fouling behavior caused by dextran was deeply and systematically investigated by employing four poly(vinylidene fluoride)(PVDF)membranes with different pore sizes, ranging from 24 to 94 nm. The extent of fouling by dextran was accurately characterized by pore reduction, flux decline, and the change of critical flux. The result shows that membrane with the smallest pore size of 24 nm experienced the smallest fouling rate and the lowest fouling extent. As the membrane pore size increased, the critical flux ranges were 105-114, 63-73, 38-44 and 34-43 L·m^(-2)·h^(-1),respectively. The critical flux and fouling resistances indicated that the fouling propensity increases with the increase of membrane pore size. Two pilot membrane modules with mean pore size of 25 nm and 60 nm were applied in membrane filtration of surface water treatment. The results showed that serious irreversible membrane fouling occurred on the membrane with pore size of 60 nm at the permeate flux of40.5 L·m^(-2)·h^(-1).On the other hand, membrane with pore size of 25 nm exhibited much better anti-fouling performance when permeate flux was set to 40.5,48 and 60 L·m^(-2)·h^(-1).

关键词：纤维膜 poly 葡聚糖氟化物毛孔行为缩放微观结构

Effect of different additives on the phase separation behavior and thermodynamics of p-tert-alkylphenoxy poly (oxyethylene) ether in absence and presence of drug

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Chinese Journal of Chemical Engineering 2018年第5期26卷 1110-1118页

作者： Marzia Rahman Md. Anamul Hoque Mohammed Abdullah Khan Malik Abdul Rub Abdullah M. Asiri Department of Chemistry Jahangirnagar University Savar Dhaka 1342 Bangladesh Chemistry Department Faculty of Science King Abdulaziz University Jeddah 21589 Saudi Arabia Center of Excellence for Advanced Materials Research King Abdulaziz UniversityJeddah 21589 Saudi Arabia

Cloud point(CP) determinations of 4-(1,1,3,3-tetramethylbutyl)phenyl-polyethylene glycol(TX-100(nonionic surfactant)) was carried out in aqueous as well as in the attendance of drug(ceftriaxone sodium trihydrate(CFT))/(CFT + different inorganic salts) and discussed thoroughly. Nonionic surfactants are employed extensively in different formulations. In aqueous solution, the values of CP of TX-100 are obtained to increase by means of enhancing of their concentration in the solution. The CP values of TX-100 solutions were found to decrease in the presence of drug and their values decrease more with rising concentrations of the drug. The values of CP of CFT and TX-100 mixtures were found to further decrease in the attendance of inorganic salts in comparison to their absence. The effect of different sodium salts in decreasing CP values of TX-100 was achieved in the following order: NaCO_3 > Na_2SO_4 > Na Cl. However, in the case of potassium and ammonium salts, the decreasing order obtained is K_2SO_4 > KCO_3 > KCl and(NH4)2 SO_4 > Na_2CO_3 > NH_4Cl respectively. Various thermodynamic parameters for example standard free energy(ΔG_c~Θ), standard enthalpy(ΔH_c~Θ) as well as standard entropy(Δ Sc?)changes of phase separation were also evaluated and discussed in detail on the basis of their behavior.

关键词：分离行为热力学 poly TX-100 添加剂表面活化剂聚乙烯乙二醇 Na2SO4