The role of statins in both cognitive impairment and protection against dementia:a tale of two mechanisms

作     者：Bob G.Schultz Denise K.Patten Daniel J.Berlau 

作者机构：Regis University School of Pharmacy3333 Regis Boulevard H-28DenverCO 80221USA 

出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)

年 卷 期：2018年第7卷第1期

页      面：43-53页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Statin Cognition Dementia Memory Cholesterol Alzheimer’s disease Vascular dementia Neuroprotection 

摘      要：Nearly 30% of adults 40 years and older in the United States are on a *** widespread use heightens the importance of careful consideration of their varied effects on the *** randomized controlled trials have not confirmed cognitive impairing effects with statins,continuing evidence suggests statins have the ability to cause reversible cognitive impairment in some ***,statins have also been shown to decrease the risk of dementia,Alzheimer’s disease,and improve cognitive impairment in some ***,randomized controlled trials have similarly failed to find the beneficial *** evidence for both claims is compelling whereas known limitations of the clinical trials may explain the lack of *** narrative review aims to explain why there is still controversy and how both effects can,and may,be *** mechanisms that have been hypothesized for each effect are seemingly independent from one another and may explain the contradicting *** mindful of the complex effects of statins,health care providers need to be able to identify patients who are at risk for or already experiencing cognitive impairment from statin use while also identifying those who could potentially decrease their risk of dementia with statins.