Wound healing reaction:A switch from gestation to senescence

作     者：Maria-Angeles Aller Jose-Ignacio Arias Luis-Alfonso Arraez-Aybar Carlos Gilsanz Jaime Arias 

作者机构：Surgery DepartmentSchool of MedicineComplutense University of Madrid28040 MadridSpain General Surgery UnitMonte Naranco Hospital Monte Naranco HospitalOviedoAsturias33012 OviedoSpain Department of Human Anatomy and Embryology ⅡSchool of MedicineComplutense University of Madrid28040 MadridSpain General Surgery UnitSureste HospitalArganda del Rey28040 MadridSpain 

出 版 物：《World Journal of Experimental Medicine》 (世界实验医学杂志)

年 卷 期：2014年第4卷第2期

页      面：16-26页

学科分类：10[医学] 

主　　题：Wound healing Repair Embryonic mechanisms Vitelline Amniotic 

摘      要：The repair of wounded tissue during postnatal life could be associated with the upregulation of some functions characteristic of the initial phases of embryonic development. The focusing of these recapitulated systemic functions in the interstitial space of the injured tissue is established through a heterogeneous endothelial barrier which has excretory-secretory abilities which in turn,would induce a gastrulation-like process. The repair of adult tissues using upregulated embryonic mechanisms could explain the universality of the inflammatory response against injury,regardless of its etiology. However,the early activation after the injury of embryonic mechanisms does not always guarantee tissue regeneration since their long-term execution is mediated by the host organism.