Role of bevacizumab in colorectal cancer growth and its adverse effects:A review

作     者：Efstathios T Pavlidis Theodoros E Pavlidis 

作者机构：Second Surgical Propedeutic Department Medical School Aristotle University of Thessaloniki Hippocration Hospital 54642 Thessaloniki Greece 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第31期

页      面：5051-5060页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Angiogenesis Vascular endothelial growth factor Anti-angiogenic agents Bevacizumab Avastin Cancer targeted therapy Colorectal cancer 

摘      要：Angiogenesis affects both wound healing and malignant cell growth through nutrients and *** endothelial growth factor(VEGF) is the most important element involved in this complex *** of VEGF influences angiogenesis and may restrict tumor growth and metastatic *** antiangiogenic therapy is based on this *** is a recombinant humanized monoclonal antibody(immunoglobulin G1) which binds with VEGF-A forming a large *** can not be bound with VEGF tyrosine kinase receptors preventing VEGF-A incorporation;thus its activity is inhibited inducing blockage of VEGFmediated ***,in combination with chemotherapy or other novel targeted therapeutic agents,is currently used more frequently in clinical practice,mainly for managing advanced colorectal *** is also used for managing other malignancies,such as breast cancer,pancreatic cancer,prostate cancer,non small-cell lung cancer,metastatic renal carcinoma and ovarian *** it is generally considered a safe treatment,there are reports of some rare side effects which should be taken into *** experiments in rats and mice show promising results with a wider therapeutic range.