Transgenic plants for allergen-specific immunotherapy
Transgenic plants for allergen-specific immunotherapy作者机构：Allergy and Immunology ProjectTokyo Metropolitan Institute of Medical ScienceTokyo 156-8506Japan Genetically Modified Organism Research CenterNational Institute of Agrobiological SciencesIbaraki 305-8602Japan
出 版 物：《World Journal of Immunology》 (世界免疫学杂志)
年 卷 期：2014年第4卷第3期
页 面：141-148页
学科分类：12[管理学] 1204[管理学-公共管理] 120402[管理学-社会医学与卫生事业管理(可授管理学、医学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学]
基 金：Supported by Grant-in-Aid for Agri-health Project from the Ministry of Agriculture,Forestry and Fisheries of Japan JSPS KAKENHI No.24791817 and 26860122 JSPS KAKENHI No.24500501 that to Kaminuma O,No.24500501 Grantin-Aid of Mishima Kaiun Memorial Foundation
主 题：Allergic disease Asthma Oral immunother-apy Rhinitis Transgenic rice
摘 要：Allergen-specific immunotherapy （IT） is an effective treatment for allergic diseases. Although subcutane-ous and sublingual ITs are currently used, safer, easier, and more effective IT is under development. Induction of immune tolerance by oral administration of allergen has been proven, though oral IT has not been applied clinically. It is mainly because a large amount of puri-fied allergen is required to induce oral tolerance. To overcome this problem, plants, peculiarly rice, have been investigated as allergen vehicles for oral IT. Rice can store a considerable amount of expressed allergen in its seeds and the accumulated allergen is stable and resistant to gastrointestinal digestion. Therefore, we have developed transgenic rice seeds （Tg rice） in which major epitopes of cedar pollen or house dust mites are expressed. We are establishing Tg rice with dem-onstrated effcacy in murine models of allergic rhinitis and bronchial asthma by oral administration at practical doses. In addition, the amount, distribution, and aller-genicity of the expressed allergen have been improved in our Tg rice. Rice-based oral IT is a promising new concept in IT for the treatment of allergic diseases.
维普期刊数据库